Synthetic Cannabis Laced With Rat Poison a Risk to US Blood Supply, FDA Warns

Click here to access our database of Recovery Speakers

Illegal synthetic cannabis products laced with rat poison continue to be sold in the United States and pose a significant health risk not only to people who use these products but also the US blood supply, the US Food and Drug Administration (FDA) said this week in an update on the ongoing problem.

Hundreds of people in about 10 states have been hospitalized with serious and sometimes fatal bleeding linked to use of synthetic cannabinoids laced with brodifacoum, a highly lethal long-acting vitamin K antagonist anticoagulant commonly used in rat poison, the agency said on July 19.

For months, the Centers for Disease Control and Prevention (CDC) and the FDA have been warning about the dangers of illegal synthetic cannabis products that are sold under names such as K2 and Spice in convenience stores and gas stations.

“But despite our efforts, certain entities continue to bypass state and federal drug laws by making and distributing these products — often marked or labeled as ‘not for human consumption’ — and changing the structure of the synthetic chemicals to try to skirt legal requirements,” the FDA said. In some cases, makers of synthetic cannabinoids have deliberately added brodifacoum, which is thought to extend the duration of the “high.”

In an advisory issued in May, the CDC said case patients have presented with a variety of signs and symptoms of coagulopathy, including bruising, nosebleeds, excessively heavy menstrual bleeding, hematemesis, hemoptysis, hematuria, flank pain, abdominal pain, and bleeding from the gums or mouth.

At the time, more than 95 biological samples from case patients tested positive for brodifacoum.

The effects of brodifacoum are treatable, and the FDA said people who use synthetic marijuana products should be vigilant for signs of bleeding and should seek immediate medical attention.

“We also want to alert health care providers, particularly those delivering care in emergency settings, to be aware of these risks and consider the possibility of synthetic cannabinoid exposure when individuals present with unexplained bleeding,” the FDA said. “Standard coagulation tests, such as the prothrombin time, can be dramatically elevated in these settings, and prompt treatment with high doses of vitamin K and other supportive care can potentially be life-saving,” they add.

Leave a Reply